On the SEI blog I write about some of our experience at Nedbank. There are two broad categories of challenges associated with scaling process change in general or TSP in particular to larger organizations:
1) The logistics of rollout and sustainment, such as support, training, and resource coordination
2( The change management problem of motivating the staff involved to take on different roles and adopt different patterns of communication
Read about it there.
http://blog.sei.cmu.edu/post.cfm/rolling-out-tsp-organizational-performance-improvement-a-case-study
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